Help the children and families of CDG.

What is
Drug Repurposing?

Drug Repurposing comes from the idea that drugs created for one purpose might coincidentally help treat something else entirely.

Aspirin is used for pain, fever and inflammation. It has been repurposed to assist with the treatment of cardiovascular disorders.

There could be drugs already out there and on the market that help treat PIGW-CDG and other forms of CDG, we just don’t know it yet. With this project, we now have a chance to find them.

Read about the process below! We have already partnered with a lab and are raising the funds to see the project through completion.

  • 1: Yeast Model

    It all begins with yeast in a lab.

    They replicate the PIGW-CDG disease to test how yeast cells respond.

    Amazingly, the lab uses the exact mutations on Hannes’ PIGW gene to create a perfect match!

  • 2: Pilot Screening

    A sample set of ~2000 compounds.

    Introduce these to the yeast cells
    and see how they react.

    If the disease is altered in some way, we look to see if there is a scientific pattern of behavior.

  • 3: Large Screening

    A larger set of ~8000 compounds.

    Using the initial discoveries, the lab tries to solidify when the disease reacts and why.

    Because these compounds are typically on the market and safe for use, it’s a fast pathway to new treatments.